| 2022-02-25 15:00:3025 febrero, 2022 |   Jornada 1 | CD L.A. Firpo FEM vs CD Atl. Marte FEM | 15:00:303:00 pm | 0 – 1 | Estadio Sergio Torres |
| 2022-02-25 18:30:1725 febrero, 2022 |   Jornada 1 | Alianza Women vs CD FAS FEM | 18:30:176:30 pm | 4 – 4 | Estadio Atl. Las Delicias |
| 2022-02-26 10:30:4326 febrero, 2022 |   Jornada 1 | Santa Tecla FC FEM vs 11 Deportivo FC FEM | 10:30:4310:30 am | 16 – 0 | Estadio Atl. Las Delicias |
| 2022-02-26 12:30:0626 febrero, 2022 |   Jornada 1 | AD Chalatenango FEM vs AD Is. Metapán FEM | 12:30:0612:30 pm | 3 – 0 | Estadio Gregorio Martinez |
| 2022-02-26 15:00:5126 febrero, 2022 |   Jornada 1 | CD Platense FEM vs Jocoro FC FEM | 15:00:513:00 pm | 4 – 0 | Estadio Toledo Valle |
| 2022-02-26 15:30:1826 febrero, 2022 |   Jornada 1 | CD Águila FEM vs CD Mpal. Limeño FEM | 15:30:183:30 pm | 0 – 2 | Estadio Juan Francisco Barraza |
| 2022-03-04 15:00:284 marzo, 2022 | Jornada 2 | Jocoro FC FEM vs CD Atl. Marte FEM | 15:00:283:00 pm | 2 – 3 | Complejo Tierra de Fuego |
| 2022-03-04 17:15:074 marzo, 2022 | Jornada 2 | Santa Tecla FC FEM vs AD Chalatenango FEM | 17:15:075:15 pm | 1 – 0 | Estadio Atl. Las Delicias |
| 2022-03-05 11:00:115 marzo, 2022 | Jornada 2 | Alianza Women vs AD Is. Metapán FEM | 11:00:1111:00 am | 12 – 0 | Estadio Atl. Las Delicias |
| 2022-03-05 14:00:505 marzo, 2022 | Jornada 2 | CD Mpal. Limeño FEM vs CD L.A. Firpo FEM | 14:00:502:00 pm | 1 – 0 | Estadio Ramón Flores Berríos |
| 2022-03-05 14:00:595 marzo, 2022 | Jornada 2 | CD FAS FEM vs 11 Deportivo FC FEM | 14:00:592:00 pm | 8 – 0 | Estadio Oscar Alberto Quiteño |
| 2022-03-05 15:00:245 marzo, 2022 | Jornada 2 | CD Platense FEM vs CD Águila FEM | 15:00:243:00 pm | 0 – 2 | Estadio Toledo Valle |
| 2022-03-11 14:00:0411 marzo, 2022 | Jornada 3 | AD Chalatenango FEM vs CD FAS FEM | 14:00:042:00 pm | 1 – 4 | Estadio Gregorio Martinez |
| 2022-03-11 14:00:4711 marzo, 2022 | Jornada 3 | CD L.A. Firpo FEM vs CD Platense FEM | 14:00:472:00 pm | 3 – 4 | Estadio Mpal. Santa Elena |
| 2022-03-12 15:00:5012 marzo, 2022 | Jornada 3 | CD Atl. Marte FEM vs CD Mpal. Limeño FEM | 15:00:503:00 pm | 4 – 2 | Estadio Ramón Flores Berríos |
| 2022-03-13 13:00:3113 marzo, 2022 | Jornada 3 | 11 Deportivo FC FEM vs Alianza Women | 13:00:311:00 pm | 0 – 15 | Estadio Arturo Simeón Magaña |
| 2022-03-13 13:00:5313 marzo, 2022 | Jornada 3 | AD Is. Metapán FEM vs Santa Tecla FC FEM | 13:00:531:00 pm | 1 – 2 | Estadio Jorge “Calero” Suárez |
| 2022-03-13 15:00:3513 marzo, 2022 | Jornada 3 | CD Águila FEM vs Jocoro FC FEM | 15:00:353:00 pm | 7 – 2 | Estadio Juan Francisco Barraza |
| 2022-03-18 14:00:3818 marzo, 2022 | Jornada 4 | CD Mpal. Limeño FEM vs Jocoro FC FEM | 14:00:382:00 pm | 3 – 0 | Estadio Ramón Flores Berríos |
| 2022-03-18 15:00:2418 marzo, 2022 | Jornada 4 | CD FAS FEM vs AD Is. Metapán FEM | 15:00:243:00 pm | 8 – 0 | Estadio Oscar Alberto Quiteño |
| 2022-03-18 15:00:4818 marzo, 2022 | Jornada 4 | 11 Deportivo FC FEM vs AD Chalatenango FEM | 15:00:483:00 pm | 0 – 0 | Estadio Arturo Simeón Magaña |
| 2022-03-19 15:00:2019 marzo, 2022 | Jornada 4 | CD Platense FEM vs CD Atl. Marte FEM | 15:00:203:00 pm | 2 – 1 | Estadio Toledo Valle |
| 2022-03-20 15:00:1120 marzo, 2022 | Jornada 4 | CD Águila FEM vs CD L.A. Firpo FEM | 15:00:113:00 pm | 4 – 2 | Estadio Municipal Luis Ulloa |
| 2022-03-20 18:00:4920 marzo, 2022 | Jornada 4 | Alianza Women vs Santa Tecla FC FEM | 18:00:496:00 pm | 1 – 0 | Estadio Atl. Las Delicias |
| 2022-03-24 11:00:2624 marzo, 2022 | Jornada 5 | AD Chalatenango FEM vs Alianza Women | 11:00:2611:00 am | 2 – 5 | Estadio Gregorio Martinez |
| 2022-03-24 14:00:1924 marzo, 2022 | Jornada 5 | CD Mpal. Limeño FEM vs CD Platense FEM | 14:00:192:00 pm | 2 – 2 | Estadio Ramón Flores Berríos |
| 2022-03-25 14:00:4725 marzo, 2022 | Jornada 5 | CD L.A. Firpo FEM vs Jocoro FC FEM | 14:00:472:00 pm | 2 – 2 | Estadio Mpal. Santa Elena |
| 2022-03-26 11:00:2426 marzo, 2022 | Jornada 5 | CD Atl. Marte FEM vs CD Águila FEM | 11:00:2411:00 am | 0 – 3 | Estadio Vitoria Gasteiz |
| 2022-03-26 19:00:0626 marzo, 2022 | Jornada 5 | Santa Tecla FC FEM vs CD FAS FEM | 19:00:067:00 pm | 1 – 2 | Estadio Atl. Las Delicias |
| 2022-04-01 14:00:111 abril, 2022 | Jornada 6 | AD Is. Metapán FEM vs AD Chalatenango FEM | 14:00:112:00 pm | 0 – 1 | Estadio Jorge “Calero” Suárez |
| 2022-04-01 15:00:071 abril, 2022 | Jornada 6 | Jocoro FC FEM vs CD Platense FEM | 15:00:073:00 pm | 0 – 6 | Complejo Tierra de Fuego |
| 2022-04-02 10:00:222 abril, 2022 | Jornada 6 | CD Atl. Marte FEM vs CD L.A. Firpo FEM | 10:00:2210:00 am | 2 – 1 | Estadio Vitoria Gasteiz |
| 2022-04-02 14:00:322 abril, 2022 | Jornada 6 | CD Mpal. Limeño FEM vs CD Águila FEM | 14:00:322:00 pm | 1 – 1 | Estadio Ramón Flores Berríos |
| 2022-04-02 15:00:222 abril, 2022 | Jornada 6 | 11 Deportivo FC FEM vs Santa Tecla FC FEM | 15:00:223:00 pm | 0 – 7 | Estadio Arturo Simeón Magaña |
| 2022-04-02 15:00:482 abril, 2022 | Jornada 6 | CD FAS FEM vs Alianza Women | 15:00:483:00 pm | 4 – 3 | Estadio Oscar Alberto Quiteño |
| 2022-04-07 15:30:427 abril, 2022 | Jornada 7 | CD Atl. Marte FEM vs Jocoro FC FEM | 15:30:423:30 pm | 5 – 0 | Estadio Vitoria Gasteiz |
| 2022-04-08 14:00:258 abril, 2022 | Jornada 7 | AD Chalatenango FEM vs Santa Tecla FC FEM | 14:00:252:00 pm | 0 – 2 | Estadio Gregorio Martinez |
| 2022-04-08 14:00:418 abril, 2022 | Jornada 7 | CD L.A. Firpo FEM vs CD Mpal. Limeño FEM | 14:00:412:00 pm | 0 – 4 | Estadio Mpal. Santa Elena |
| 2022-04-09 15:00:129 abril, 2022 | Jornada 7 | CD Águila FEM vs CD Platense FEM | 15:00:123:00 pm | 5 – 2 | Estadio Municipal Luis Ulloa |
| 2022-04-10 15:00:1010 abril, 2022 | Jornada 7 | AD Is. Metapán FEM vs Alianza Women | 15:00:103:00 pm | 0 – 1 | Estadio Jorge “Calero” Suárez |
| 2022-04-10 15:00:2110 abril, 2022 | Jornada 7 | 11 Deportivo FC FEM vs CD FAS FEM | 15:00:213:00 pm | 0 – 12 | Estadio Arturo Simeón Magaña |
| 2022-04-14 10:00:0114 abril, 2022 | Jornada 8 | CD FAS FEM vs AD Chalatenango FEM | 10:00:0110:00 am | 7 – 0 | Estadio Oscar Alberto Quiteño |
| 2022-04-14 15:00:1514 abril, 2022 | Jornada 8 | Jocoro FC FEM vs CD Águila FEM | 15:00:153:00 pm | 0 – 6 | Complejo Tierra de Fuego |
| 2022-04-14 15:30:2014 abril, 2022 | Jornada 8 | CD Atl. Marte FEM vs CD Mpal. Limeño FEM | 15:30:203:30 pm | 1 – 2 | Estadio Vitoria Gasteiz |
| 2022-04-16 15:00:4916 abril, 2022 | Jornada 8 | CD Platense FEM vs CD L.A. Firpo FEM | 15:00:493:00 pm | 4 – 0 | Estadio Toledo Valle |
| 2022-04-16 15:30:2316 abril, 2022 | Jornada 8 | Santa Tecla FC FEM vs AD Is. Metapán FEM | 15:30:233:30 pm | 5 – 0 | Estadio Atl. Las Delicias |
| 2022-04-17 18:00:1517 abril, 2022 | Jornada 8 | Alianza Women vs 11 Deportivo FC FEM | 18:00:156:00 pm | 9 – 1 | Estadio Atl. Las Delicias |
| 2022-04-22 14:00:0222 abril, 2022 | Jornada 9 | AD Chalatenango FEM vs 11 Deportivo FC FEM | 14:00:022:00 pm | 4 – 0 | Estadio Gregorio Martinez |
| 2022-04-22 14:00:0922 abril, 2022 | Jornada 9 | CD L.A. Firpo FEM vs CD Águila FEM | 14:00:092:00 pm | 0 – 3 | Estadio Mpal. Santa Elena |
| 2022-04-22 15:00:0622 abril, 2022 | Jornada 9 | Jocoro FC FEM vs CD Mpal. Limeño FEM | 15:00:063:00 pm | 1 – 6 | Complejo Tierra de Fuego |
| 2022-04-22 18:30:4022 abril, 2022 | Jornada 9 | Santa Tecla FC FEM vs Alianza Women | 18:30:406:30 pm | 1 – 5 | Estadio Atl. Las Delicias |
| 2022-04-23 10:00:3623 abril, 2022 | Jornada 9 | CD Atl. Marte FEM vs CD Platense FEM | 10:00:3610:00 am | 0 – 2 | Estadio Vitoria Gasteiz |
| 2022-04-23 15:00:1923 abril, 2022 | Jornada 9 | AD Is. Metapán FEM vs CD FAS FEM | 15:00:193:00 pm | 2 – 15 | Estadio Jorge “Calero” Suárez |
| 2022-04-28 15:00:5228 abril, 2022 | Jornada 5 | AD Is. Metapán FEM vs 11 Deportivo FC FEM | 15:00:523:00 pm | 3 – 1 | Estadio Jorge “Calero” Suárez |
| 2022-04-29 15:00:1529 abril, 2022 | Jornada 10 | Jocoro FC FEM vs CD L.A. Firpo FEM | 15:00:153:00 pm | 3 – 2 | Complejo Tierra de Fuego |
| 2022-04-29 15:00:2529 abril, 2022 | Jornada 10 | CD Platense FEM vs CD Mpal. Limeño FEM | 15:00:253:00 pm | 0 – 1 | Estadio Toledo Valle |
| 2022-04-30 18:00:3630 abril, 2022 | Jornada 10 | Alianza Women vs AD Chalatenango FEM | 18:00:366:00 pm | 5 – 1 | Estadio Atl. Las Delicias |
| 2022-05-01 15:00:251 mayo, 2022 | Jornada 10 | 11 Deportivo FC FEM vs AD Is. Metapán FEM | 15:00:253:00 pm | 1 – 2 | Estadio Arturo Simeón Magaña |
| 2022-05-02 15:00:022 mayo, 2022 | Jornada 10 | CD FAS FEM vs Santa Tecla FC FEM | 15:00:023:00 pm | 3 – 0 | Estadio Oscar Alberto Quiteño |
| 2022-05-04 15:00:194 mayo, 2022 | Jornada 10 | CD Águila FEM vs CD Atl. Marte FEM | 15:00:193:00 pm | 3 – 0 | Municipal de Quelepa |
