| 2022-01-15 15:00:5015 enero, 2022 |   Jornada 1 | Reserva CD LA. Firpo vs Reserva CD Mpal. Limeño | 15:00:503:00 pm | 1 - 1 | Estadio Sergio Torres |
| 2022-01-15 16:00:2715 enero, 2022 |   Jornada 1 | Reservas CD Águila vs Reserva Jocoro FC | 16:00:274:00 pm | 1 - 1 | Estadio Juan Francisco Barraza |
| 2022-01-15 19:00:4715 enero, 2022 |   Jornada 1 | Reserva Sta. Tecla FC vs Reservas CD Platense | 19:00:477:00 pm | 3 - 2 | Estadio Atl. Las Delicias |
| 2022-01-16 12:00:3916 enero, 2022 |   Jornada 1 | Reserva Alianza FC vs Reserva ADI Metapán | 12:00:3912:00 pm | 3 - 1 | Estadio Cuscatlán |
| 2022-01-16 12:00:5416 enero, 2022 |   Jornada 1 | Reserva 11 Deportivo FC vs Reservas CD FAS | 12:00:5412:00 pm | 0 - 0 | Estadio Arturo Simeón Magaña |
| 2022-01-16 12:30:4516 enero, 2022 |   Jornada 1 | Reserva AD Chalatenango vs Reserva CD Atl. Marte | 12:30:4512:30 pm | 2 - 5 | Estadio Gregorio Martinez |
| 2022-01-22 12:15:2822 enero, 2022 | Jornada 2 | Reserva Jocoro FC vs Reserva Alianza FC | 12:15:2812:15 pm | 0 - 2 | Complejo Tierra de Fuego |
| 2022-01-22 15:00:1922 enero, 2022 | Jornada 2 | Reserva ADI Metapán vs Reserva AD Chalatenango | 15:00:193:00 pm | 1 - 1 | Estadio Jorge “Calero” Suárez |
| 2022-01-22 15:00:3822 enero, 2022 | Jornada 2 | Reserva Sta. Tecla FC vs Reserva 11 Deportivo FC | 15:00:383:00 pm | 3 - 1 | Estadio Atl. Las Delicias |
| 2022-01-23 12:00:0223 enero, 2022 | Jornada 2 | Reserva CD Atl. Marte vs Reserva CD LA. Firpo | 12:00:0212:00 pm | 1 - 1 | Estadio Cuscatlán |
| 2022-01-23 12:00:2123 enero, 2022 | Jornada 2 | Reservas CD FAS vs Reservas CD Águila | 12:00:2112:00 pm | 0 - 1 | Estadio Oscar Alberto Quiteño |
| 2022-01-23 12:30:3423 enero, 2022 | Jornada 2 | Reserva CD Mpal. Limeño vs Reservas CD Platense | 12:30:3412:30 pm | 1 - 1 | Estadio Ramón Flores Berríos |
| 2022-01-26 11:00:5026 enero, 2022 | Jornada 3 | Reservas CD Platense vs Reserva CD Atl. Marte | 11:00:5011:00 am | 3 - 4 | Estadio Toledo Valle |
| 2022-01-26 12:00:4426 enero, 2022 | Jornada 3 | Reserva 11 Deportivo FC vs Reserva CD Mpal. Limeño | 12:00:4412:00 pm | 1 - 2 | Estadio Arturo Simeón Magaña |
| 2022-01-26 12:30:2026 enero, 2022 | Jornada 3 | Reserva Jocoro FC vs Reservas CD FAS | 12:30:2012:30 pm | 2 - 0 | Complejo Tierra de Fuego |
| 2022-01-26 16:00:2126 enero, 2022 | Jornada 3 | Reserva Alianza FC vs Reserva AD Chalatenango | 16:00:214:00 pm | 6 - 1 | Estadio Cuscatlán |
| 2022-01-26 16:00:2426 enero, 2022 | Jornada 3 | Reserva CD LA. Firpo vs Reserva ADI Metapán | 16:00:244:00 pm | 2 - 2 | Estadio Sergio Torres |
| 2022-01-26 16:00:4526 enero, 2022 | Jornada 3 | Reservas CD Águila vs Reserva Sta. Tecla FC | 16:00:454:00 pm | 4 - 0 | Estadio Juan Francisco Barraza |
| 2022-01-29 12:00:1929 enero, 2022 | Jornada 4 | Reserva CD Atl. Marte vs Reserva 11 Deportivo FC | 12:00:1912:00 pm | 1 - 2 | Estadio Cuscatlán |
| 2022-01-29 15:00:0129 enero, 2022 | Jornada 4 | Reserva ADI Metapán vs Reservas CD Platense | 15:00:013:00 pm | 4 - 1 | Estadio Jorge “Calero” Suárez |
| 2022-01-29 15:00:1429 enero, 2022 | Jornada 4 | Reserva AD Chalatenango vs Reserva CD LA. Firpo | 15:00:143:00 pm | 1 - 2 | Estadio Gregorio Martinez |
| 2022-01-29 15:15:5829 enero, 2022 | Jornada 4 | Reserva Sta. Tecla FC vs Reserva Jocoro FC | 15:15:583:15 pm | 4 - 1 | Estadio Atl. Las Delicias |
| 2022-01-30 12:00:3630 enero, 2022 | Jornada 4 | Reserva CD Mpal. Limeño vs Reservas CD Águila | 12:00:3612:00 pm | 0 - 2 | Estadio Ramón Flores Berríos |
| 2022-02-04 12:30:384 febrero, 2022 | Jornada 5 | Reserva Jocoro FC vs Reserva CD Mpal. Limeño | 12:30:3812:30 pm | 1 - 1 | Complejo Tierra de Fuego |
| 2022-02-05 16:00:205 febrero, 2022 | Jornada 5 | Reservas CD Águila vs Reserva CD Atl. Marte | 16:00:204:00 pm | 1 - 0 | Estadio Juan Francisco Barraza |
| 2022-02-06 11:00:286 febrero, 2022 | Jornada 5 | Reservas CD Platense vs Reserva AD Chalatenango | 11:00:2811:00 am | 2 - 0 | Estadio Toledo Valle |
| 2022-02-06 12:00:026 febrero, 2022 | Jornada 5 | Reserva Alianza FC vs Reserva CD LA. Firpo | 12:00:0212:00 pm | 3 - 2 | Estadio Cuscatlán |
| 2022-02-06 12:00:476 febrero, 2022 | Jornada 5 | Reservas CD FAS vs Reserva Sta. Tecla FC | 12:00:4712:00 pm | 2 - 4 | Estadio Oscar Alberto Quiteño |
| 2022-02-06 12:00:516 febrero, 2022 | Jornada 5 | Reserva 11 Deportivo FC vs Reserva ADI Metapán | 12:00:5112:00 pm | 2 - 2 | Estadio Arturo Simeón Magaña |
| 2022-02-09 12:00:029 febrero, 2022 | Jornada 6 | Reserva CD Mpal. Limeño vs Reservas CD FAS | 12:00:0212:00 pm | 0 - 2 | Estadio Ramón Flores Berríos |
| 2022-02-09 12:00:499 febrero, 2022 | Jornada 6 | Reserva CD Atl. Marte vs Reserva Jocoro FC | 12:00:4912:00 pm | 1 - 0 | Estadio Cuscatlán |
| 2022-02-09 15:00:369 febrero, 2022 | Jornada 6 | Reserva AD Chalatenango vs Reserva 11 Deportivo FC | 15:00:363:00 pm | 1 - 0 | Estadio Gregorio Martinez |
| 2022-02-09 15:00:409 febrero, 2022 | Jornada 6 | Reserva ADI Metapán vs Reservas CD Águila | 15:00:403:00 pm | 2 - 2 | Estadio Jorge “Calero” Suárez |
| 2022-02-09 15:30:379 febrero, 2022 | Jornada 6 | Reserva Sta. Tecla FC vs Reserva Alianza FC | 15:30:373:30 pm | 2 - 0 | Estadio Atl. Las Delicias |
| 2022-02-09 16:00:419 febrero, 2022 | Jornada 6 | Reserva CD LA. Firpo vs Reservas CD Platense | 16:00:414:00 pm | 0 - 2 | Estadio Sergio Torres |
| 2022-02-12 12:30:1112 febrero, 2022 | Jornada 7 | Reserva Jocoro FC vs Reserva ADI Metapán | 12:30:1112:30 pm | 0 - 1 | Complejo Tierra de Fuego |
| 2022-02-12 15:15:0312 febrero, 2022 | Jornada 7 | Reserva Sta. Tecla FC vs Reserva CD Mpal. Limeño | 15:15:033:15 pm | 1 - 2 | Estadio Atl. Las Delicias |
| 2022-02-12 16:00:0612 febrero, 2022 | Jornada 7 | Reservas CD Águila vs Reserva AD Chalatenango | 16:00:064:00 pm | 2 - 1 | Estadio Juan Francisco Barraza |
| 2022-02-13 12:00:0913 febrero, 2022 | Jornada 7 | Reserva 11 Deportivo FC vs Reserva CD LA. Firpo | 12:00:0912:00 pm | 0 - 1 | Estadio Arturo Simeón Magaña |
| 2022-02-13 12:00:1313 febrero, 2022 | Jornada 7 | Reserva Alianza FC vs Reservas CD Platense | 12:00:1312:00 pm | 3 - 2 | Estadio Cuscatlán |
| 2022-02-13 12:00:2013 febrero, 2022 | Jornada 7 | Reservas CD FAS vs Reserva CD Atl. Marte | 12:00:2012:00 pm | 0 - 0 | Estadio Oscar Alberto Quiteño |
| 2022-02-19 12:00:4819 febrero, 2022 | Jornada 8 | Reserva CD Atl. Marte vs Reserva Sta. Tecla FC | 12:00:4812:00 pm | 2 - 1 | Estadio Cuscatlán |
| 2022-02-19 15:00:1319 febrero, 2022 | Jornada 8 | Reserva ADI Metapán vs Reservas CD FAS | 15:00:133:00 pm | 1 - 0 | Estadio Jorge “Calero” Suárez |
| 2022-02-19 15:00:3219 febrero, 2022 | Jornada 8 | Reserva AD Chalatenango vs Reserva Jocoro FC | 15:00:323:00 pm | 1 - 0 | Estadio Gregorio Martinez |
| 2022-02-19 16:00:0919 febrero, 2022 | Jornada 8 | Reserva CD LA. Firpo vs Reservas CD Águila | 16:00:094:00 pm | 0 - 1 | Estadio Sergio Torres |
| 2022-02-20 11:00:0720 febrero, 2022 | Jornada 8 | Reservas CD Platense vs Reserva 11 Deportivo FC | 11:00:0711:00 am | 3 - 2 | Estadio Toledo Valle |
| 2022-02-20 12:00:1320 febrero, 2022 | Jornada 8 | Reserva CD Mpal. Limeño vs Reserva Alianza FC | 12:00:1312:00 pm | 3 - 4 | Estadio Ramón Flores Berríos |
| 2022-02-23 11:00:4123 febrero, 2022 | Jornada 9 | Reserva CD Mpal. Limeño vs Reserva CD Atl. Marte | 11:00:4111:00 am | 0 - 0 | Estadio Ramón Flores Berríos |
| 2022-02-23 11:00:4623 febrero, 2022 | Jornada 9 | Reserva 11 Deportivo FC vs Reserva Alianza FC | 11:00:4611:00 am | 1 - 1 | Estadio Arturo Simeón Magaña |
| 2022-02-23 12:00:1123 febrero, 2022 | Jornada 9 | Reservas CD FAS vs Reserva AD Chalatenango | 12:00:1112:00 pm | 5 - 3 | Estadio Oscar Alberto Quiteño |
| 2022-02-23 12:30:4823 febrero, 2022 | Jornada 9 | Reserva Jocoro FC vs Reserva CD LA. Firpo | 12:30:4812:30 pm | 2 - 0 | Complejo Tierra de Fuego |
| 2022-02-23 15:30:2323 febrero, 2022 | Jornada 9 | Reserva Sta. Tecla FC vs Reserva ADI Metapán | 15:30:233:30 pm | 5 - 2 | Estadio Atl. Las Delicias |
| 2022-02-23 16:00:2723 febrero, 2022 | Jornada 9 | Reservas CD Águila vs Reservas CD Platense | 16:00:274:00 pm | 3 - 0 | Estadio Juan Francisco Barraza |
| 2022-02-26 15:00:4526 febrero, 2022 | Jornada 10 | Reserva ADI Metapán vs Reserva CD Mpal. Limeño | 15:00:453:00 pm | 0 - 1 | Estadio Jorge “Calero” Suárez |
| 2022-02-26 15:00:5926 febrero, 2022 | Jornada 10 | Reserva AD Chalatenango vs Reserva Sta. Tecla FC | 15:00:593:00 pm | 4 - 1 | Estadio Gregorio Martinez |
| 2022-02-26 16:00:5626 febrero, 2022 | Jornada 10 | Reserva CD LA. Firpo vs Reservas CD FAS | 16:00:564:00 pm | 0 - 0 | Estadio Sergio Torres |
| 2022-02-27 11:00:2927 febrero, 2022 | Jornada 10 | Reserva 11 Deportivo FC vs Reservas CD Águila | 11:00:2911:00 am | 1 - 1 | Estadio Arturo Simeón Magaña |
| 2022-02-27 11:00:5127 febrero, 2022 | Jornada 10 | Reservas CD Platense vs Reserva Jocoro FC | 11:00:5111:00 am | 1 - 0 | Estadio Toledo Valle |
| 2022-02-27 12:15:2627 febrero, 2022 | Jornada 10 | Reserva Alianza FC vs Reserva CD Atl. Marte | 12:15:2612:15 pm | 3 - 1 | Estadio Cuscatlán |
| 2022-03-02 16:00:152 marzo, 2022 | Jornada 4 | Reserva Alianza FC vs Reservas CD FAS | 16:00:154:00 pm | 1 - 1 | Estadio Cuscatlán |
| 2022-03-05 11:00:535 marzo, 2022 | Jornada 11 | Reserva CD Atl. Marte vs Reserva ADI Metapán | 11:00:5311:00 am | 1 - 3 | Estadio Vitoria Gasteiz |
| 2022-03-05 12:30:115 marzo, 2022 | Jornada 11 | Reserva Jocoro FC vs Reserva 11 Deportivo FC | 12:30:1112:30 pm | 1 - 2 | Complejo Tierra de Fuego |
| 2022-03-05 15:15:225 marzo, 2022 | Jornada 11 | Reserva Sta. Tecla FC vs Reserva CD LA. Firpo | 15:15:223:15 pm | 2 - 0 | Estadio Atl. Las Delicias |
| 2022-03-06 12:00:006 marzo, 2022 | Jornada 11 | Reserva Alianza FC vs Reservas CD Águila | 12:00:0012:00 pm | 3 - 2 | Estadio Cuscatlán |
| 2022-03-06 12:00:056 marzo, 2022 | Jornada 11 | Reservas CD FAS vs Reservas CD Platense | 12:00:0512:00 pm | 2 - 1 | Estadio Oscar Alberto Quiteño |
| 2022-03-06 12:00:546 marzo, 2022 | Jornada 11 | Reserva CD Mpal. Limeño vs Reserva AD Chalatenango | 12:00:5412:00 pm | 1 - 1 | Estadio Ramón Flores Berríos |
| 2022-03-11 15:00:4111 marzo, 2022 | Jornada 12 | Reserva Jocoro FC vs Reservas CD Águila | 15:00:413:00 pm | 1 - 1 | Complejo Tierra de Fuego |
| 2022-03-12 12:00:1312 marzo, 2022 | Jornada 12 | Reserva CD Atl. Marte vs Reserva AD Chalatenango | 12:00:1312:00 pm | 3 - 2 | Estadio Cuscatlán |
| 2022-03-12 15:00:1212 marzo, 2022 | Jornada 12 | Reserva ADI Metapán vs Reserva Alianza FC | 15:00:123:00 pm | 1 - 3 | Estadio Jorge “Calero” Suárez |
| 2022-03-13 11:00:0413 marzo, 2022 | Jornada 12 | Reservas CD FAS vs Reserva 11 Deportivo FC | 11:00:0411:00 am | 0 - 2 | Estadio Oscar Alberto Quiteño |
| 2022-03-13 12:00:5513 marzo, 2022 | Jornada 12 | Reserva CD Mpal. Limeño vs Reserva CD LA. Firpo | 12:00:5512:00 pm | 0 - 2 | Estadio Ramón Flores Berríos |
| 2022-03-13 15:00:4213 marzo, 2022 | Jornada 12 | Reservas CD Platense vs Reserva Sta. Tecla FC | 15:00:423:00 pm | 2 - 1 | Estadio Toledo Valle |
| 2022-03-19 12:30:2019 marzo, 2022 | Jornada 13 | Reserva 11 Deportivo FC vs Reserva Sta. Tecla FC | 12:30:2012:30 pm | 0 - 0 | Estadio Arturo Simeón Magaña |
| 2022-03-19 15:00:0619 marzo, 2022 | Jornada 13 | Reserva AD Chalatenango vs Reserva ADI Metapán | 15:00:063:00 pm | 2 - 2 | Estadio Gregorio Martinez |
| 2022-03-19 16:00:1419 marzo, 2022 | Jornada 13 | Reserva CD LA. Firpo vs Reserva CD Atl. Marte | 16:00:144:00 pm | 1 - 0 | Estadio Sergio Torres |
| 2022-03-19 16:00:4719 marzo, 2022 | Jornada 13 | Reservas CD Águila vs Reservas CD FAS | 16:00:474:00 pm | 3 - 0 | Estadio Juan Francisco Barraza |
| 2022-03-19 16:00:5319 marzo, 2022 | Jornada 13 | Reserva Alianza FC vs Reserva Jocoro FC | 16:00:534:00 pm | 8 - 1 | Estadio Cuscatlán |
| 2022-03-20 11:00:1220 marzo, 2022 | Jornada 13 | Reservas CD Platense vs Reserva CD Mpal. Limeño | 11:00:1211:00 am | 1 - 3 | Estadio Toledo Valle |
| 2022-03-23 12:00:0323 marzo, 2022 | Jornada 14 | Reserva CD Atl. Marte vs Reservas CD Platense | 12:00:0312:00 pm | 1 - 4 | Estadio Cuscatlán |
| 2022-03-23 12:00:4323 marzo, 2022 | Jornada 14 | Reservas CD FAS vs Reserva Jocoro FC | 12:00:4312:00 pm | 2 - 2 | Estadio Oscar Alberto Quiteño |
| 2022-03-23 15:00:5023 marzo, 2022 | Jornada 14 | Reserva ADI Metapán vs Reserva CD LA. Firpo | 15:00:503:00 pm | 2 - 1 | Estadio Jorge “Calero” Suárez |
| 2022-03-23 15:15:5523 marzo, 2022 | Jornada 14 | Reserva Sta. Tecla FC vs Reservas CD Águila | 15:15:553:15 pm | 3 - 2 | Estadio Atl. Las Delicias |
| 2022-03-24 15:00:3824 marzo, 2022 | Jornada 14 | Reserva AD Chalatenango vs Reserva Alianza FC | 15:00:383:00 pm | 3 - 2 | Estadio Gregorio Martinez |
| 2022-03-25 12:00:5325 marzo, 2022 | Jornada 14 | Reserva CD Mpal. Limeño vs Reserva 11 Deportivo FC | 12:00:5312:00 pm | 1 - 1 | Estadio Ramón Flores Berríos |
| 2022-04-02 12:30:132 abril, 2022 | Jornada 15 | Reserva Jocoro FC vs Reserva Sta. Tecla FC | 12:30:1312:30 pm | 1 - 0 | Complejo Tierra de Fuego |
| 2022-04-02 15:30:222 abril, 2022 | Jornada 15 | Reservas CD Águila vs Reserva CD Mpal. Limeño | 15:30:223:30 pm | 2 - 0 | Estadio Juan Francisco Barraza |
| 2022-04-03 11:00:123 abril, 2022 | Jornada 15 | Reservas CD Platense vs Reserva ADI Metapán | 11:00:1211:00 am | 3 - 2 | Estadio Toledo Valle |
| 2022-04-03 11:00:353 abril, 2022 | Jornada 15 | Reservas CD FAS vs Reserva Alianza FC | 11:00:3511:00 am | 0 - 0 | Estadio Oscar Alberto Quiteño |
| 2022-04-03 11:00:553 abril, 2022 | Jornada 15 | Reserva 11 Deportivo FC vs Reserva CD Atl. Marte | 11:00:5511:00 am | 1 - 0 | Estadio Arturo Simeón Magaña |
| 2022-04-03 12:00:593 abril, 2022 | Jornada 15 | Reserva CD LA. Firpo vs Reserva AD Chalatenango | 12:00:5912:00 pm | 0 - 0 | Estadio Sergio Torres |
| 2022-04-09 15:00:089 abril, 2022 | Jornada 16 | Reserva AD Chalatenango vs Reservas CD Platense | 15:00:083:00 pm | 5 - 1 | Estadio Gregorio Martinez |
| 2022-04-09 15:00:409 abril, 2022 | Jornada 16 | Reserva ADI Metapán vs Reserva 11 Deportivo FC | 15:00:403:00 pm | 2 - 1 | Estadio Jorge “Calero” Suárez |
| 2022-04-09 15:00:559 abril, 2022 | Jornada 16 | Reserva Sta. Tecla FC vs Reservas CD FAS | 15:00:553:00 pm | 3 - 0 | Estadio Atl. Las Delicias |
| 2022-04-10 12:00:0510 abril, 2022 | Jornada 16 | Reserva CD LA. Firpo vs Reserva Alianza FC | 12:00:0512:00 pm | 0 - 1 | Estadio Sergio Torres |
| 2022-04-10 12:00:0710 abril, 2022 | Jornada 16 | Reserva CD Mpal. Limeño vs Reserva Jocoro FC | 12:00:0712:00 pm | 1 - 0 | Estadio Ramón Flores Berríos |
| 2022-04-12 12:00:3612 abril, 2022 | Jornada 16 | Reserva CD Atl. Marte vs Reservas CD Águila | 12:00:3612:00 pm | 1 - 1 | Estadio Cuscatlán |
| 2022-04-13 11:00:1013 abril, 2022 | Jornada 17 | Reservas CD Platense vs Reserva CD LA. Firpo | 11:00:1011:00 am | 2 - 0 | Estadio Toledo Valle |
| 2022-04-13 11:00:1813 abril, 2022 | Jornada 17 | Reserva 11 Deportivo FC vs Reserva AD Chalatenango | 11:00:1811:00 am | 2 - 0 | Estadio Arturo Simeón Magaña |
| 2022-04-13 12:00:1913 abril, 2022 | Jornada 17 | Reservas CD FAS vs Reserva CD Mpal. Limeño | 12:00:1912:00 pm | 3 - 1 | Estadio Oscar Alberto Quiteño |
| 2022-04-13 12:00:4713 abril, 2022 | Jornada 17 | Reserva Alianza FC vs Reserva Sta. Tecla FC | 12:00:4712:00 pm | 3 - 2 | Estadio Cuscatlán |
| 2022-04-13 12:30:5013 abril, 2022 | Jornada 17 | Reserva Jocoro FC vs Reserva CD Atl. Marte | 12:30:5012:30 pm | 0 - 1 | Complejo Tierra de Fuego |
| 2022-04-13 15:00:4013 abril, 2022 | Jornada 17 | Reservas CD Águila vs Reserva ADI Metapán | 15:00:403:00 pm | 6 - 3 | Estadio Juan Francisco Barraza |
| 2022-04-16 15:00:3516 abril, 2022 | Jornada 18 | Reserva AD Chalatenango vs Reservas CD Águila | 15:00:353:00 pm | 3 - 4 | Estadio Gregorio Martinez |
| 2022-04-16 15:00:4916 abril, 2022 | Jornada 18 | Reserva ADI Metapán vs Reserva Jocoro FC | 15:00:493:00 pm | 1 - 1 | Estadio Jorge “Calero” Suárez |
| 2022-04-17 11:00:2817 abril, 2022 | Jornada 18 | Reservas CD Platense vs Reserva Alianza FC | 11:00:2811:00 am | 2 - 4 | Estadio Toledo Valle |
| 2022-04-17 12:00:0717 abril, 2022 | Jornada 18 | Reserva CD Atl. Marte vs Reservas CD FAS | 12:00:0712:00 pm | 1 - 0 | Estadio Cuscatlán |
| 2022-04-17 12:00:3117 abril, 2022 | Jornada 18 | Reserva CD LA. Firpo vs Reserva 11 Deportivo FC | 12:00:3112:00 pm | 2 - 1 | Estadio Sergio Torres |
| 2022-04-17 12:00:5517 abril, 2022 | Jornada 18 | Reserva CD Mpal. Limeño vs Reserva Sta. Tecla FC | 12:00:5512:00 pm | 0 - 1 | Estadio Ramón Flores Berríos |
| 2022-04-23 12:30:5923 abril, 2022 | Jornada 19 | Reserva Jocoro FC vs Reserva AD Chalatenango | 12:30:5912:30 pm | 1 - 0 | Complejo Tierra de Fuego |
| 2022-04-23 15:00:3023 abril, 2022 | Jornada 19 | Reserva Sta. Tecla FC vs Reserva CD Atl. Marte | 15:00:303:00 pm | 1 - 1 | Estadio Atl. Las Delicias |
| 2022-04-23 16:00:0323 abril, 2022 | Jornada 19 | Reservas CD Águila vs Reserva CD LA. Firpo | 16:00:034:00 pm | 2 - 0 | Estadio Juan Francisco Barraza |
| 2022-04-24 11:00:3524 abril, 2022 | Jornada 19 | Reserva 11 Deportivo FC vs Reservas CD Platense | 11:00:3511:00 am | 1 - 4 | Estadio Arturo Simeón Magaña |
| 2022-04-24 11:00:5424 abril, 2022 | Jornada 19 | Reservas CD FAS vs Reserva ADI Metapán | 11:00:5411:00 am | 2 - 4 | Estadio Oscar Alberto Quiteño |
| 2022-04-24 12:00:4124 abril, 2022 | Jornada 19 | Reserva Alianza FC vs Reserva CD Mpal. Limeño | 12:00:4112:00 pm | 6 - 0 | Estadio Cuscatlán |
| 2022-04-27 11:00:2227 abril, 2022 | Jornada 20 | Reservas CD Platense vs Reservas CD Águila | 11:00:2211:00 am | 0 - 2 | Estadio Toledo Valle |
| 2022-04-27 12:00:2427 abril, 2022 | Jornada 20 | Reserva CD Atl. Marte vs Reserva CD Mpal. Limeño | 12:00:2412:00 pm | 1 - 3 | Estadio Cuscatlán |
| 2022-04-27 15:00:1527 abril, 2022 | Jornada 20 | Reserva AD Chalatenango vs Reservas CD FAS | 15:00:153:00 pm | 3 - 6 | Estadio Gregorio Martinez |
| 2022-04-27 15:00:4527 abril, 2022 | Jornada 20 | Reserva CD LA. Firpo vs Reserva Jocoro FC | 15:00:453:00 pm | 3 - 0 | Estadio Sergio Torres |
| 2022-04-27 15:00:5227 abril, 2022 | Jornada 20 | Reserva ADI Metapán vs Reserva Sta. Tecla FC | 15:00:523:00 pm | 0 - 3 | Estadio Jorge “Calero” Suárez |
| 2022-04-28 16:15:1928 abril, 2022 | Jornada 20 | Reserva Alianza FC vs Reserva 11 Deportivo FC | 16:15:194:15 pm | 0 - 1 | Estadio Cuscatlán |
| 2022-04-30 12:30:1530 abril, 2022 | Jornada 21 | Reserva Jocoro FC vs Reservas CD Platense | 12:30:1512:30 pm | 2 - 4 | Complejo Tierra de Fuego |
| 2022-04-30 15:00:4230 abril, 2022 | Jornada 21 | Reservas CD Águila vs Reserva 11 Deportivo FC | 15:00:423:00 pm | 0 - 2 | Estadio Juan Francisco Barraza |
| 2022-05-01 01:00:391 mayo, 2022 | Jornada 21 | Reserva Sta. Tecla FC vs Reserva AD Chalatenango | 01:00:391:00 am | 2 - 3 | Estadio Atl. Las Delicias |
| 2022-05-01 12:00:211 mayo, 2022 | Jornada 21 | Reservas CD FAS vs Reserva CD LA. Firpo | 12:00:2112:00 pm | 1 - 1 | Estadio Oscar Alberto Quiteño |
| 2022-05-01 12:00:501 mayo, 2022 | Jornada 21 | Reserva CD Atl. Marte vs Reserva Alianza FC | 12:00:5012:00 pm | 4 - 2 | Estadio Cuscatlán |
| 2022-05-01 12:00:531 mayo, 2022 | Jornada 21 | Reserva CD Mpal. Limeño vs Reserva ADI Metapán | 12:00:5312:00 pm | 3 - 4 | Estadio Ramón Flores Berríos |
| 2022-05-07 12:00:087 mayo, 2022 | Jornada 22 | Reserva AD Chalatenango vs Reserva CD Mpal. Limeño | 12:00:0812:00 pm | 4 - 2 | Estadio Gregorio Martinez |
| 2022-05-07 12:00:257 mayo, 2022 | Jornada 22 | Reserva ADI Metapán vs Reserva CD Atl. Marte | 12:00:2512:00 pm | 3 - 0 | Estadio Jorge “Calero” Suárez |
| 2022-05-07 12:00:257 mayo, 2022 | Jornada 22 | Reserva 11 Deportivo FC vs Reserva Jocoro FC | 12:00:2512:00 pm | 4 - 1 | Estadio Arturo Simeón Magaña |
| 2022-05-08 11:00:058 mayo, 2022 | Jornada 22 | Reservas CD Águila vs Reserva Alianza FC | 11:00:0511:00 am | 3 - 3 | Estadio Juan Francisco Barraza |
| 2022-05-08 12:00:308 mayo, 2022 | Jornada 22 | Reserva CD LA. Firpo vs Reserva Sta. Tecla FC | 12:00:3012:00 pm | 6 - 2 | Estadio Sergio Torres |
| 2022-05-08 12:00:398 mayo, 2022 | Jornada 22 | Reservas CD Platense vs Reservas CD FAS | 12:00:3912:00 pm | 3 - 0 | Estadio Toledo Valle |
