| 2021-03-20 12:00:2920 marzo, 2021 |   Jornada 1 | Reserva Sonsonate FC vs Reserva CD Atl. Marte | 12:00:2912:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Ana Mercedes Campos |
| 2021-03-21 12:30:0121 marzo, 2021 |   Jornada 1 | Reservas CD Águila vs Reserva Sta. Tecla FC | 12:30:0112:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Juan Francisco Barraza |
| 2021-03-21 14:30:0221 marzo, 2021 |   Jornada 1 | Reservas CD FAS vs Reserva CD LA. Firpo | 14:30:022:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Oscar Alberto Quiteño |
| 2021-03-21 15:00:2221 marzo, 2021 |   Jornada 1 | Reserva AD Chalatenango vs Reserva 11 Deportivo FC | 15:00:223:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Gregorio Martinez |
| 2021-03-21 15:00:4721 marzo, 2021 |   Jornada 1 | Reserva ADI Metapán vs Reserva CD Mpal. Limeño | 15:00:473:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Jorge “Calero” Suárez |
| 2021-03-21 15:30:2021 marzo, 2021 |   Jornada 1 | Reserva Jocoro FC vs Reserva Alianza FC | 15:30:203:30 pm | Reservas Clausura 2021-FASE 2 | Complejo Tierra de Fuego |
| 2021-03-27 12:30:4427 marzo, 2021 | Jornada 2 | Reservas CD Águila vs Reservas CD FAS | 12:30:4412:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Juan Francisco Barraza |
| 2021-03-27 12:30:5627 marzo, 2021 | Jornada 2 | Reserva CD Atl. Marte vs Reserva ADI Metapán | 12:30:5612:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Vitoria Gasteiz |
| 2021-03-27 13:00:0427 marzo, 2021 | Jornada 2 | Reserva Jocoro FC vs Reserva Sonsonate FC | 13:00:041:00 pm | Reservas Clausura 2021-FASE 2 | Complejo Tierra de Fuego |
| 2021-03-30 13:15:1630 marzo, 2021 | Jornada 2 | Reserva CD LA. Firpo vs Reserva AD Chalatenango | 13:15:161:15 pm | Reservas Clausura 2021-FASE 2 | Estadio Sergio Torres |
| 2021-03-30 14:30:1430 marzo, 2021 | Jornada 2 | Reserva Sta. Tecla FC vs Reserva 11 Deportivo FC | 14:30:142:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Atl. Las Delicias |
| 2021-03-30 15:00:0230 marzo, 2021 | Jornada 2 | Reserva Alianza FC vs Reserva CD Mpal. Limeño | 15:00:023:00 pm | Reservas Clausura 2021-FASE 2 | Cancha #1, FESFUT |
| 2021-04-03 10:30:223 abril, 2021 | Jornada 3 | Reservas CD FAS vs Reserva Sta. Tecla FC | 10:30:2210:30 am | Reservas Clausura 2021-FASE 2 | Estadio Oscar Alberto Quiteño |
| 2021-04-03 10:30:263 abril, 2021 | Jornada 3 | Reserva 11 Deportivo FC vs Reserva CD LA. Firpo | 10:30:2610:30 am | Reservas Clausura 2021-FASE 2 | Estadio Arturo Simeón Magaña |
| 2021-04-03 14:30:473 abril, 2021 | Jornada 3 | Reserva AD Chalatenango vs Reservas CD Águila | 14:30:472:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Gregorio Martinez |
| 2021-04-03 15:00:253 abril, 2021 | Jornada 3 | Reserva Sonsonate FC vs Reserva Alianza FC | 15:00:253:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Ana Mercedes Campos |
| 2021-04-03 15:00:403 abril, 2021 | Jornada 3 | Reserva CD Mpal. Limeño vs Reserva CD Atl. Marte | 15:00:403:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Ramón Flores Berríos |
| 2021-04-04 15:00:114 abril, 2021 | Jornada 3 | Reserva ADI Metapán vs Reservas Jocoro FC | 15:00:113:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Jorge “Calero” Suárez |
| 2021-04-06 14:00:026 abril, 2021 | Jornada 4 | Reserva Alianza FC vs Reserva CD Atl. Marte | 14:00:022:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Cuscatlán |
| 2021-04-07 09:00:237 abril, 2021 | Jornada 4 | Reserva Jocoro FC vs Reserva CD Mpal. Limeño | 09:00:239:00 am | Reservas Clausura 2021-FASE 2 | Complejo Tierra de Fuego |
| 2021-04-07 10:00:457 abril, 2021 | Jornada 4 | Reservas CD FAS vs Reserva AD Chalatenango | 10:00:4510:00 am | Reservas Clausura 2021-FASE 2 | Estadio Oscar Alberto Quiteño |
| 2021-04-07 12:00:267 abril, 2021 | Jornada 4 | Reserva Sonsonate FC vs Reserva ADI Metapán | 12:00:2612:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Ana Mercedes Campos |
| 2021-04-07 12:30:257 abril, 2021 | Jornada 4 | Reservas CD Águila vs Reserva 11 Deportivo FC | 12:30:2512:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Juan Francisco Barraza |
| 2021-04-08 14:30:108 abril, 2021 | Jornada 4 | Reserva Sta. Tecla FC vs Reserva CD LA. Firpo | 14:30:102:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Atl. Las Delicias |
| 2021-04-10 12:00:3510 abril, 2021 | Jornada 5 | Reserva 11 Deportivo FC vs Reservas CD FAS | 12:00:3512:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Arturo Simeón Magaña |
| 2021-04-10 12:30:3710 abril, 2021 | Jornada 5 | Reserva CD Atl. Marte vs Reserva Jocoro FC | 12:30:3712:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Vitoria Gasteiz |
| 2021-04-10 13:00:0710 abril, 2021 | Jornada 5 | Reserva CD LA. Firpo vs Reservas CD Águila | 13:00:071:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Sergio Torres |
| 2021-04-10 14:30:3110 abril, 2021 | Jornada 5 | Reservas AD Chalatenango vs Reserva Sta. Tecla Fc | 14:30:312:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Gregorio Martinez |
| 2021-04-11 12:00:4911 abril, 2021 | Jornada 5 | Reserva CD Mpal. Limeño vs Reserva Sonsonate FC | 12:00:4912:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Ramón Flores Berríos |
| 2021-04-11 15:15:2611 abril, 2021 | Jornada 5 | Reserva ADI Metapán vs Reserva Alianza FC | 15:15:263:15 pm | Reservas Clausura 2021-FASE 2 | Estadio Jorge “Calero” Suárez |
| 2021-04-16 12:30:0116 abril, 2021 | Jornada 6 | Reserva CD LA. Firpo vs Reservas CD FAS | 12:30:0112:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Sergio Torres |
| 2021-04-16 14:30:2016 abril, 2021 | Jornada 6 | Reserva 11 Deportivo FC vs Reserva AD Chalatenango | 14:30:202:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Arturo Simeón Magaña |
| 2021-04-17 12:30:5517 abril, 2021 | Jornada 6 | Reserva CD Atl. Marte vs Reserva Sonsonate FC | 12:30:5512:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Vitoria Gasteiz |
| 2021-04-17 14:30:5317 abril, 2021 | Jornada 6 | Reserva Sta. Tecla FC vs Reservas CD Águila | 14:30:532:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Atl. Las Delicias |
| 2021-04-17 16:00:1817 abril, 2021 | Jornada 6 | Reserva Alianza FC vs Reserva Jocoro FC | 16:00:184:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Cuscatlán |
| 2021-04-18 11:00:5218 abril, 2021 | Jornada 6 | Reserva CD Mpal. Limeño vs Reserva ADI Metapán | 11:00:5211:00 am | Reservas Clausura 2021-FASE 2 | Estadio Ramón Flores Berríos |
| 2021-04-21 12:30:4721 abril, 2021 | Jornada 7 | Reserva Sonsonate FC vs Reserva Jocoro FC | 12:30:4712:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Ana Mercedes Campos |
| 2021-04-21 14:30:3621 abril, 2021 | Jornada 7 | Reserva AD Chalatenango vs Reserva CD LA. Firpo | 14:30:362:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Gregorio Martinez |
| 2021-04-21 15:00:4621 abril, 2021 | Jornada 7 | Reserva ADI Metapán vs Reserva CD Atl. Marte | 15:00:463:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Jorge “Calero” Suárez |
| 2021-04-22 09:30:3622 abril, 2021 | Jornada 7 | Reserva 11 Deportivo FC vs Reserva Sta. Tecla FC | 09:30:369:30 am | Reservas Clausura 2021-FASE 2 | Estadio Arturo Simeón Magaña |
| 2021-04-22 14:00:0722 abril, 2021 | Jornada 7 | Reservas CD FAS vs Reservas CD Águila | 14:00:072:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Oscar Alberto Quiteño |
| 2021-04-22 14:00:2022 abril, 2021 | Jornada 7 | Reserva CD Mpal. Limeño vs Reserva Alianza FC | 14:00:202:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Ramón Flores Berríos |
| 2021-04-24 10:00:4424 abril, 2021 | Jornada 8 | Reserva Sta. Tecla FC vs Reservas CD FAS | 10:00:4410:00 am | Reservas Clausura 2021-FASE 2 | Estadio Atl. Las Delicias |
| 2021-04-24 12:30:0124 abril, 2021 | Jornada 8 | Reservas CD Águila vs Reserva AD Chalatenango | 12:30:0112:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Juan Francisco Barraza |
| 2021-04-24 15:30:3624 abril, 2021 | Jornada 8 | Reserva Jocoro FC vs Reserva ADI Metapán | 15:30:363:30 pm | Reservas Clausura 2021-FASE 2 | Complejo Tierra de Fuego |
| 2021-04-25 13:30:4325 abril, 2021 | Jornada 8 | Reserva CD Atl. Marte vs Reserva CD Mpal. Limeño | 13:30:431:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Vitoria Gasteiz |
| 2021-04-25 15:00:5325 abril, 2021 | Jornada 8 | Reserva Alianza FC vs Reserva Sonsonate FC | 15:00:533:00 pm | Reservas Clausura 2021-FASE 2 | Cancha #1, FESFUT |
| 2021-04-26 13:00:5926 abril, 2021 | Jornada 8 | Reserva CD LA. Firpo vs Reserva 11 Deportivo FC | 13:00:591:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Sergio Torres |
| 2021-04-29 14:30:0729 abril, 2021 | Jornada 9 | Reserva ADI Metapán vs Reserva Sonsonate FC | 14:30:072:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Jorge “Calero” Suárez |
| 2021-04-29 14:30:0829 abril, 2021 | Jornada 9 | Reserva CD LA. Firpo vs Reserva Sta. Tecla FC | 14:30:082:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Sergio Torres |
| 2021-04-29 14:30:0829 abril, 2021 | Jornada 9 | Reserva AD Chalatenango vs Reservas CD FAS | 14:30:082:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Gregorio Martinez |
| 2021-04-29 14:30:2029 abril, 2021 | Jornada 9 | Reserva CD Mpal. Limeño vs Reserva Jocoro FC | 14:30:202:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Ramón Flores Berríos |
| 2021-04-29 14:30:2629 abril, 2021 | Jornada 9 | Reserva CD Atl. Marte vs Reserva Alianza FC | 14:30:262:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Vitoria Gasteiz |
| 2021-04-29 14:30:5529 abril, 2021 | Jornada 9 | Reserva 11 Deportivo FC vs Reservas CD Águila | 14:30:552:30 pm | Reservas Clausura 2021-FASE 2 | Estadio Arturo Simeón Magaña |
| 2021-05-02 13:00:062 mayo, 2021 | Jornada 10 | Reserva Jocoro FC vs Reserva CD Atl. Marte | 13:00:061:00 pm | Reservas Clausura 2021-FASE 2 | Complejo Tierra de Fuego |
| 2021-05-02 13:00:092 mayo, 2021 | Jornada 10 | Reservas CD Águila vs Reserva CD LA. Firpo | 13:00:091:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Juan Francisco Barraza |
| 2021-05-02 13:00:132 mayo, 2021 | Jornada 10 | Reserva Sta. Tecla FC vs Reserva AD Chalatenango | 13:00:131:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Atl. Las Delicias |
| 2021-05-02 13:00:222 mayo, 2021 | Jornada 10 | Reserva Alianza FC vs Reserva ADI Metapán | 13:00:221:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Cuscatlán |
| 2021-05-02 13:00:302 mayo, 2021 | Jornada 10 | Reservas CD FAS vs Reserva 11 Deportivo FC | 13:00:301:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Oscar Alberto Quiteño |
| 2021-05-02 13:00:332 mayo, 2021 | Jornada 10 | Reserva Sonsonate FC vs Reserva CD Mpal. Limeño | 13:00:331:00 pm | Reservas Clausura 2021-FASE 2 | Estadio Ana Mercedes Campos |
